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Total Synthesis and Biological Evaluation of (−)-9-Deoxy-englerin A

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NIAID Data Ecosystem2026-03-07 收录
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An effective total synthesis of (−)-9-deoxy-englerin (4), an analogue of the natural guaiane sesquiterpene englerin A (1), has been achieved. The synthesis features a transannular epoxide opening to construct the 5,7-fused ring system followed by transannular ether formation with mercury(II) trifluoroacetate.

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2011-04-15
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