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Variants that modify CSF Aβ<sub>42</sub> levels affect risk for AD, whereas variants associated with CSF ptau<sub>181</sub> levels affect rate of progression.

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NIAID Data Ecosystem2026-03-06 收录
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P-values for the association of rs1868402 (PPP3R1) and APOE4 with CSF Aß42 and ptau181 levels, risk for AD, age at onset and disease progression are shown. *Sample size = 846; WU-ADRC-CSF+ADNI-CSF+UW. **Sample size = 2322 MRC+WU ADRC-CC+ADNI-CC. ***Sample size = 259; WU-ADRC-CSF+ADNI-CSF with low CSF Aβ42 levels. Significant p-values are in bold.

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2010-09-16
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