G551D/F508del subjects.

Summary of results for CF subjects with G551D mutations. Six adult G551D CF subjects were tested. Table is arranged by subject and condition, each row shows the results for a single test or means/sums when multiple tests were performed. Subjects had been taking ivacaftor for at least 3 weeks prior to (+) ivacaftor testing. Columns labeled ‘gland numbers’ show the number of glands that secreted to an intradermal injection of MCh, then to the β-adrenergic cocktail at the same site (C-sweat), and the ratio of the two expressed as a percentage. Columns labeled ‘gland volumes/rates’ show the average final M-sweat or C-sweat volumes per gland expressed as nanoliters for a 15 min period (M-sweat) or 30 min period (C-sweat) followed by average rates (per min, per gland). The 4 columns labeled ‘ratios’ show: 1) the mean C-sweat rate as a percent of the mean M-sweat rate; 2) the C/M ratios as a percentage of the average C/M ratio of 0.2651 obtained for 6 control subjects [10]; 3) that value for the 12 glands having the highest M-sweat rates; and 4) the value for the 12 highest glands after correcting for sweat volume loss.