Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism (bulkRNA-seq)

Differences in female and male immunity may contribute to variations in response to infections and predisposition to autoimmunity. The characterization of the mechanisms that drive differential neutrophil phenotypes between genders has been investigated. This provides new insights that distinct sex difference in neutrophil biology related to responses to type I IFNs, immunometabolism and maturation status that may have prominent functional and pathogenic implications. The transcriptome of neutrophils from healthy adult males and females was characterized using bulk RNASeq. The transcriptome of whole blood leukocytes was elucidated using scRNASeq. The RNAseq dataset includes a total of 14 individual samples. The scRNASeq dataset includes a total of 7 individual samples. This study sought to characterize sex differences in neutrophil biology. Transcriptomic profiles of neutrophils from healthy adult males and females were characterized.