High-throughput transcriptomics of Celf1 conditional knockout lens identifies downstream networks linked to cataract pathology. High-throughput transcriptomics of Celf1 conditional knockout lens identifies downstream networks linked to cataract pathology

Celf1 germline or conditional deletion mouse mutants exhibit fully penetrant lens defects including cataract. To gain insight into gene expression changes underlying these lens defects Differential Gene Expression analysis was performed for lenses obtained from control and Celf1 conditional deletion mutant mice. Overall design: Differential Gene Expression analysis of RNA-seq data from lens of P0 mice Celf1 cko or Control, from mixed background (C57BL/6J ; FVB) control (Celf1lacZKI/+)and mutant (Celf1cKO) mice was performed