Defects in the mitochondrial genome of dogs with recurrent tumours

This study presents a comprehensive analysis of mitochondrial DNA (mtDNA) variations in dogs diagnosed with primary and recurrent tumors, employing Oxford Nanopore Technologies (ONT) for sequencing. Our investigation focused on mtDNA extracted from blood and tumor tissues of three dogs, aiming to pinpoint polymorphisms, mutations, and heteroplasmy levels that could in-fluence the mitochondrial function in cancer pathogenesis.