ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand MRL871

ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand MRL871 Descriptor: 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-1H-indazol-3-yl}benzoic acid, GLYCEROL, Nuclear receptor ROR-gamma, ... Authors: de Vries, R.M.J.M, Meijer, F.A, Brunsveld, L. Deposit date: 2019-10-14 Release date: 2020-11-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t. Proc.Natl.Acad.Sci.USA, 118, 2021与链甾醇（desmosterol）及变构配体MRL871形成复合物的RORγt配体结合域。描述项：4-{1-[2-氯-6-(三氟甲基)苯甲酰基]-1H-吲唑-3-基}苯甲酸、甘油（GLYCEROL）、核受体RORγt等。作者：de Vries, R.M.J.M、Meijer, F.A、Brunsveld, L。提交日期：2019-10-14，发布日期：2020-11-18，最后修改日期：2024-01-24。实验方法：X射线衍射（分辨率1.89 Å）。引用文献：《RORγt的正构与变构配体结合位点间的协同作用》，《美国国家科学院院刊》，118卷，2021年