Lipids and Neurotransmitters Mass Spectrometry Imaging Data from Dopaminergic PSAP Deficient (cPSAP^DAT) and Serotonergic PSAP deficient (cPSAP^SERT) Mice Brain Tissue sections

The files above are MALDI-MSI (Matrix Assisted Laser Desorption Ionization - Mass Spectrometry Imaging) experiments. The dataset contains both imzML, which is the common MSI open file type containing x, y positions in tissue as well as m/z and intensity, which is a more user friendly format. The data contained in this dataset should be enough to recreate the MSI parts of the manuscript. Prosaposin (PSAP) modulates glycosphingolipid metabolism and may relate to Parkinson’s disease (PD). Here, the lipids and neurotransmitters MALDI-MSI data have been collected from dopaminergic PSAP-deficient (cPSAP^DAT) mice and serotonergic PSAP-deficient (cPSAP^SERT) mice as well as 6-OHDA-induced Parkinson's disease mouse model.<br>For any questions about the dataset or to request access to any files not uploaded here, please contact [e-mail]上述文件为基质辅助激光解吸电离-质谱成像（Matrix Assisted Laser Desorption Ionization - Mass Spectrometry Imaging，MALDI-MSI）实验相关数据。本数据集包含imzML格式文件——这是当前主流的质谱成像开源文件格式，可存储组织样本的x、y空间位置信息以及质荷比（m/z）与信号强度数据，是更为友好易用的文件格式。本数据集涵盖的数据足以复现论文手稿中质谱成像部分的相关内容。鞘脂激活蛋白原（Prosaposin，PSAP）可调控糖鞘脂代谢，且可能与帕金森病（Parkinson’s disease，PD）存在关联。本研究收集了多巴胺能PSAP缺陷型（cPSAP^DAT）小鼠、5-羟色胺能PSAP缺陷型（cPSAP^SERT）小鼠以及6-羟基多巴胺（6-OHDA）诱导的帕金森病小鼠模型的脂质与神经递质MALDI-MSI数据。若您对本数据集有任何疑问，或需要获取本页面未上传的相关文件，请联系[e-mail]