Eosinophils promote larval growth in an innate context.

(A)–(C), C57BL/6, PHIL, Rag1-/-, PHIL/Rag1-/- and Rag2-/-γc-/- mice were injected IV with 25,000 NBL. (A) Body size (area) of larvae recovered from indicated strains 13 days post injection. (B) Body size (area) of larvae recovered from Rag1-/- and Rag2-/-γc-/- mice, 13 days post injection. (C) PHIL/Rag1-/- mice received PBS or 5 × 106 eosinophils from infected IL-5Tg+ or IL-5Tg+/IL-4-/- mice every 48 h from 0–5 days post IV infection. Body size (area) of larvae, 13 days post injection. Each data set was collected from two experiments with similar results. Values represent mean ± SD; n = 3–4 mice. Significant differences were determined by Student’s t test or ANOVA and Tukey’s test. ***p < 0.0001.