Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-difluoromethylene triphosphate

Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-difluoromethylene triphosphate Descriptor: 2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINE, 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ... Authors: Sucato, C.A, Upton, T.G, Kashemirov, B.A, Martinek, V, Xiang, Y, Beard, W.A. Deposit date: 2006-10-18 Release date: 2007-01-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Modifying the beta,gamma Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase beta. Biochemistry, 46, 2007DNA聚合酶β（DNA Polymerase beta）与双脱氧终止引物以及2'-脱氧鸟苷5'-β,γ-二氟亚甲基三磷酸的三元复合物 描述物：2'-脱氧-5'-O-[({[二氟(膦酰基)甲基](羟基)膦酰基}氧基)(羟基)膦酰基]鸟苷，5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'，5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'，…… 作者：Sucato, C.A.、Upton, T.G.、Kashemirov, B.A.、Martinek, V.、Xiang, Y.、Beard, W.A. 提交日期：2006-10-18 发布日期：2007-01-30 最后修改日期：2023-08-30 实验方法：X射线衍射（2.1 Å） 引用文献：《修饰β,γ-离去基团桥接氧可改变DNA聚合酶β的核苷酸掺入效率、保真度与催化机制》，《生物化学》，第46卷，2007年