Crystal Structure of BlaC covalently bound with Doripenem

Crystal Structure of BlaC covalently bound with Doripenem Descriptor: (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION Authors: Tremblay, L.W, Blanchard, J.S. Deposit date: 2009-08-19 Release date: 2010-04-14 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. Biochemistry, 49, 2010与多尼培南共价结合的BlaC晶体结构 配体描述：(2S,3R,4S)-2-[(2S,3R)-3-羟基-1-氧代丁-2-基]-3-甲基-4-({(3S,5S)-5-[(磺酰氨基)甲基]吡咯烷-3-基}硫烷基)-3,4-二氢-2H-吡咯-5-羧酸、β-内酰胺酶（Beta-lactamase）与磷酸根离子 作者：Tremblay, L.W.、Blanchard, J.S. 提交日期：2009-08-19 发布日期：2010-04-14 最后更新：2024-11-06 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.2 Å 引用文献：《结核分枝杆菌β-内酰胺酶与碳青霉烯类厄他培南、多尼培南的生化与结构表征》，《生物化学》，第49卷，2010年