Whole transcriptomics data under different extracellular matrix stiffness in NB cells

Nuclear pore complex (NPC), the gatekeepers of macromolecules across the nuclear envelope (NE), undergoes dynamic changes pivotal in physiology and pathology. Our study established ECM stiffness as a key driver of NB cell migration through a novel lamin A/C/E2F4/PLK1 axis, which governed post-mitotic NPC assembly and nucleocytoplasmic transport function. Targeting NPC-mediated transport may represent a promising therapeutic strategy for NB. Overall design: Analyzing whole transcriptomic profiles across different stiffness conditions aims to investigate how substrate stiffness influences gene expression and signaling pathways in neuroblastoma cells.