Evaluating an Esr1-mutant novel cell population emerging upon ERα-antagonism by bulk ATAC-seq. Evaluating an Esr1-mutant novel cell population emerging upon ERα-antagonism by bulk ATAC-seq
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA846354
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To examine the effects of ERα antagonism (giredestrant) on Esr1-wildtype and Esr1-mutant mammary glands, animals were treated with hormone pellets (E2, P4), then dosed daily with vehicle (MCT) or giredestrant (30 mg/kg, p.o.) for four days. Following dosing, individual mammary epithelial cell populations were FACS-isolated and sequenced. Overall design: To examine the effects of ERα antagonism (giredestrant) on Esr1-wildtype and Esr1-mutant mammary glands, animals were treated with hormone pellets (E2, P4), then dosed daily with vehicle (MCT) or giredestrant for four days. 51 samples are included, 3 biological replicates per condition.
创建时间：
2022-06-06
