Summary of adult eye morphology frequency results at different stages of the study.

For morphology classification, “Mild” indicates mildly abnormal morphology and “Severe” indicates severely abnormal morphology.†P-values for stage-1, stage-3 and stage-4 crosses are for Fisher's Exact tests of the proportion of severely abnormal eyes tested against the proportion in the Le-Cre+/+; Pax6+/+ plus the Le-Cre+/+; Pax6fl/+ control groups. For the PAX77 crosses, P-values are for Fisher's Exact tests of the proportion of severely abnormal eyes for Le-CreTg/-; Pax6+/+; PAX77Tg/- versus Le-CreTg/-; Pax6+/+; PAX77-/- and for Le-CreTg/-; Pax6fl/+; PAX77Tg/- versus Le-CreTg/-; Pax6fl/+; PAX77-/-.*P***P††Two Le-CreTg/-; Pax6+/+ mice from stage-1 crosses had a very mild phenotype (irido-corneal angles appeared partly closed) – see Fig. 2D.Summary of adult eye morphology frequency results at different stages of the study.