Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2-chlorophenyl)ethyl)amino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2-chlorophenyl)ethyl)amino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-{[(3R,4R)-4-(2-{[2-(2-chlorophenyl)-2,2-difluoroethyl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine, ACETATE ION, ... Authors: Li, H, Delker, S, Poulos, T.L. Deposit date: 2010-11-18 Release date: 2011-11-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase. J.Med.Chem., 54, 2011

与6-(((3R,4R)-4-(2-((2,2-二氟-2-(2-氯苯基)乙基)氨基)乙氧基)吡咯烷-3-基)甲基)-4-甲基吡啶-2-胺结合的大鼠神经元型一氧化氮合酶（neuronal nitric oxide synthase）血红素结构域（heme domain）结构
描述物：5,6,7,8-四氢生物蝶呤（5,6,7,8-TETRAHYDROBIOPTERIN）、6-{[(3R,4R)-4-(2-{[2-(2-氯苯基)-2,2-二氟乙基]氨基}乙氧基)吡咯烷-3-基]甲基}-4-甲基吡啶-2-胺、乙酸根离子（ACETATE ION）等
作者：Li, H、Delker, S、Poulos, T.L.
提交日期：2010-11-18
发布日期：2011-11-02
最后修改日期：2023-09-06
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.94埃
引用文献：手性吡咯烷类抑制剂的优化合成及其与神经元型一氧化氮合酶的结合特性，《药物化学杂志》（J.Med.Chem.），54卷，2011年