Spatial transcriptomics reveal lineage complexity of gastric incomplete intestinal metaplasia and its association with gastric cancers [ATAC-Seq]

This research underscores the unique molecular phenotype and lineage complexity of Inc IM, emphasizing its significance as a precancerous lesion in gastric tissues. Our findings lay the groundwork for future investigations into the epigenetic and transcriptional dynamics governing metaplastic changes, highlighting the importance of Inc IM in GC progression. Overall design: Bulk ATACseq profiles of Human gastric organoids ( naGF_ATAC, IncomGF_ATAC and ComGF_ATAC) and Intestinal orgnoids ( SI_ATAC and LI_ATAC)