Dataset for the study Sensitive period for the plasticity of alpha activity in humans

Raw EEG data in european data format (EDF) format. Descriptive and clinical data of the subjects in textual tab delimited format. Columns report for each subject: group (blind/severely impaired, BSI or sighted, S), code, gender, age expressed in decimal years, age bin, degree of visual impairment, diagnosis, motor coordination impairment classification (MCI, 1 = not impaired, 2 = impaired), and hypotonia classification (1 = not impaired, 2 = impaired).  NA correspond to undefined classification.

Visual experience is crucial for the development of neural processing. For example, alpha activity development is a vision-dependent mechanism. Indeed, studies report no alpha activity is present in blind adults. Nevertheless, studies have not investigated the developmental trajectory of this activity in infants and children with blindness. Here, we hypothesize that the difference in neural activity of blind compared to sighted subjects is: absent at birth, progressive with age, specifically occipital and linked to a gradual motor impairment. Therefore, we consider spectral power of resting-state EEG and its association with motor impairment indices, in blind subjects and in sighted controls between 0 and 11 years of age. Blind subjects show posterior alpha activity during the first three years of life, although weaker and slower maturing compared to sighted subjects. The first great differentiation between blind and sighted subjects occurs between 3 and 6 years of age. Starting in this period, reduced alpha activity increases the probability of motor impairment in blind subjects, likely because of impaired perception/interaction. These results show that visual experience mediates the neural mechanisms generating alpha oscillations during the first years of life, suggesting that it is a sensitive period for the plasticity of this process.