Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ3451 at 3.6 angstrom resolution

Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ3451 at 3.6 angstrom resolution Descriptor: 2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide, Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, SODIUM ION Authors: Cheng, R.K.Y, Fiez-Vandal, C, Schlenker, O, Edman, K, Aggeler, B, Brown, D.G, Brown, G, Cooke, R.M, Dumelin, C.E, Dore, A.S, Geschwindner, S, Grebner, C, Hermansson, N.-O, Jazayeri, A, Johansson, P, Leong, L, Prihandoko, R, Rappas, M, Soutter, H, Snijder, A, Sundstrom, L, Tehan, B, Thornton, P, Troast, D, Wiggin, G, Zhukov, A, Marshall, F.H, Dekker, N. Deposit date: 2017-03-09 Release date: 2017-05-03 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural insight into allosteric modulation of protease-activated receptor 2. Nature, 545, 2017分辨率3.6埃的、与AZ3451结合的热稳定化人蛋白酶激活受体2（protease-activated receptor-2，PAR2）的晶体结构。描述符：2-(6-溴-1,3-苯并二氧五环-5-基)-N-(4-氰基苯基)-1-[(1S)-1-环己基乙基]苯并咪唑-5-甲酰胺、溶菌酶、蛋白酶激活受体2、可溶性细胞色素b562、蛋白酶激活受体2、钠离子。作者：Cheng R.K.Y、Fiez-Vandal C、Schlenker O、Edman K、Aggeler B、Brown D.G.、Brown G、Cooke R.M.、Dumelin C.E.、Dore A.S.、Geschwindner S、Greber C、Hermansson N.-O、Jazayeri A、Johansson P、Leong L、Prihandoko R、Rappas M、Soutter H、Snijder A、Sundstrom L、Tehan B、Thornton P、Troast D、Wiggin G、Zhukov A、Marshall F.H.、Dekker N.。提交日期：2017-03-09，发布日期：2017-05-03，最后修改日期：2024-10-16。实验方法：X射线衍射（3.6 Å）。引用文献：《蛋白酶激活受体2变构调节的结构洞察》，发表于《自然》（*Nature*），第545卷，2017年。