Additional file 1 of Tissue proteome analysis for profiling proteins associated with lymph node metastasis in gallbladder cancer

Additional file 1: Supplementary Table S1. Clinical parameters of patients such as age, gender, TNM, stage, grade, white cell count, liver enzymes (AST/ ALT/ ALP), bilirubin and co-morbidities (jaundice, pulmonary tuberculosis, asthma, diabetes melitus, hypertension (HTN), loss of appetite(LOA) and LOW- Loss of weight; Foot note: NA- Not applicable, (-) Not available. Supplementary Table S2. List of 58 DEPs in LN Positive GBC. The proteins with ≥2.0 fold change and adjusted p value <0.05 were used as DEPs. The details are provided in the Methods section. The Table describes the total number of proteins and peptides identified in mass spectrometry runs along with their quantity values. Supplementary Table S3. Bioinformatic analysis of 58 DEPs in LN positive GBC using STRING databse. (A) Top 10 Molecular Functions (B) Top 10 reactome pathways. Supplementary Table S4. Literature survey of 58 DEPs for their association with LN metastasis in cancer. A total of 6 proteins are reported in GBC, 33 proteins in other cancers and 19 were found to be novel to cancer with respect to LN metastasis.