GNPS Global and targeted metabolomics characterizes antipsychotic medications, amino acid signatures, and platelet-activating factor involvement in first-episode psychosis

We performed global untargeted metabolomics by LCMS using a Q Exactive Focus mass spectrometer coupled to a Dionex U3000 UHPLC of plasma extract from patients following First Episode Psychosis. Both positive and negative reversed phase injections were performed in triplicate with replicates performed in separate batches. The Biocrates p400 kit was also used to obtain absolute quantification of 400+ metabolites using the vendor kit, column, and data processing tools as provided. The resulting global data was processed with Compound Discoverer 2.1. The resulting output is included within this upload as well as the output from the Biocrates data processing software. Data was integrated using a variety of R scripts as detailed in the associated manuscript.