Percentage of Epistatic Networks.

Percentage of Networks with Average Epistatic Coefficients Significantly Different from 0. Statistical significance was evaluated by means of sign tests (). Each matrix entry gives the percentage of networks exhibiting epistasis (either positive or negative) significantly different from 0, under different mutational conditions: epistatic coefficients of two (), three (), four () and five () orders. ANC: XTR indicates arbitrary network configurations with X Transcriptional Regulators. FNC: XTR indicates functional network configurations with X Transcriptional Regulators.