CLK1 bound with benzothiazole Tg003 (Cpd 2)

CLK1 bound with benzothiazole Tg003 (Cpd 2) Descriptor: (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one, Dual specificity protein kinase CLK1 Authors: Schroeder, M, Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2020-04-24 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.3 Å) Cite: DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity. J.Med.Chem., 63, 2020CLK1与苯并噻唑类化合物Tg003（化合物2）结合的相关描述：(Z)-1-(3-乙基-5-甲氧基-1,3-苯并噻唑-2-亚基)丙-2-酮，对应靶点为双特异性蛋白激酶CLK1。作者：Schroeder M、Chaikuad A、Knapp S，结构基因组学联盟（Structural Genomics Consortium, SGC）。提交日期：2020-04-24，发布日期：2020-07-15，最后修改日期：2024-01-24。实验方法：X射线衍射（分辨率2.3 Å）。引用文献：《残基DFG-1调控抑制剂结合模式与亲和力，为激酶抑制剂选择性的合理设计提供依据》，《药物化学杂志》，2020年，第63卷。