Altering cancer transcriptomes using epigenomic inhibitors [Illumina beadchip]

ChEBI2015-01-07 更新2026-07-21 收录

癌症表观遗传治疗

转录组药物响应

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Altering cancer transcriptomes using epigenomic inhibitors [Illumina beadchip]

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2015-01-07

Brugia pahangi depleted of peripheral Wolbachia

寄生虫-共生菌互作

转录组药物响应

This data was collected to assess the effect of rifampicin treatment on Brugia pahangi and its bacterial endosymbiont, Wolbachia, at early and late timepoints. We found that at early timepoints, Wolba

NIAID Data Ecosystem100

Suppression of adaptive responses to targeted cancer therapy by transcriptional repression [RNA-seq]. Homo sapiens

肿瘤耐药机制

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Large-scale genomic profiling efforts have facilitated the characterization of molecular alterations in cancers and aided the development of targeted kinase inhibitors for a wide array of cancer types

NIAID Data Ecosystem50

Catalytic-independent functions of INTAC confer sensitivity to BET inhibition [RNA-seq]

癌症表观遗传治疗

药物耐药机制

Chromatin and transcription regulators are critical to defining cell identity through shaping epigenetic and transcriptional landscapes, with their misregulation being closely linked to oncogenesis. P

NIAID Data Ecosystem20

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

癌症表观遗传治疗

PARP1抑制剂治疗

An "induced PARP inhibitor (PARPi) sensitivity by epigenetic modulation" strategy is being evaluated in the clinic to sensitize homologous recombination (HR) proficient tumors to PARPi treatments. To

NIAID Data Ecosystem70

SMARCA4 Phosphorilation inhibition

癌症表观遗传治疗

激酶抑制剂开发

Cyclin-Dependent Kinase 9 (CDK9) as part of the PTEFb complex promotes transcriptional elongation and high-level gene expression. We now report that, paradoxically, CDK9 is also essential for maintain

NIAID Data Ecosystem30

Altering cancer transcriptomes using epigenomic inhibitors [Illumina beadchip]

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