Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014

<b>Background:</b> The purpose of this registry study was to evaluate trends in incidence and survival of laryngeal cancer in the Danish population from 1980 to 2014. <b>Methods:</b> This study includes all patients with laryngeal cancer registered in the Danish Cancer Registry (DCR) in the period 1980–2014. The age-adjusted incidence rate (AAIR) per 100,000 and average annual percent change (AAPC) were calculated. We evaluated the relative survival at five years in relation to gender, anatomical location, year at diagnosis, and histological type. Further, an age-period-cohort (APC) model of incidence was constructed. <b>Results:</b> A total of 8748 patients (82% males) were included. The median age at diagnosis was 60 years, range 18–101 years. The AAIR decreased from 3.6 per 100,000 in 1980 to 2.3 per 100,000 in 2014 with an AAPC of –0.8% (<i>p</i> <b>Conclusions:</b> This nation-wide study reports a significant decrease in the incidence of laryngeal cancer. Glottic cancer had a significantly better survival at five years compared to other locations.