microRNA profilling in dendritic cells of systemic lupus erythematosus. Homo sapiens

Recent studies have shown that alterations in the function of dendritic cells (DCs) are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of DCs participating in SLE remains unclear. We profiled the microRNAs (miRNAs) of LPS-stimulated DCs in SLE patients and found diffentially expressed miRNAs in DCs of such group patients. Overall design: Two-condition experiment, DC (as controls) vs. SLG (as patients with SLE group) cells. Biological replicates: 5 control replicates, 5 patient replicates.