Supplementary Material for: Circuit Survival in Children with Hemolytic Uremic Syndrome Requiring Continuous Renal Replacement Therapy.

Background:
Hemolytic uremic syndrome (HUS) is a significant cause of acute kidney injury (AKI) in children that is caused by Shiga toxin-producing Escherichia coli (STEC). Continuous renal replacement therapy (CRRT) is frequently used for managing AKI in critically ill pediatric patients. The filter lifespan is a crucial factor affecting its effectiveness and cost. This study aimed to investigate the impact of HUS on the lifespan of CRRT filters compared with that of other etiologies.
Materials and Methods:
This retrospective longitudinal study was conducted in a pediatric intensive care unit (PICU) in Nancy, France, from January 2013 to December 2023. The study included 54 children requiring CRRT, with 388 filters (202 in the HUS group and 186 in the other etiologies group). Data on filter lifespan and various parameters were collected and analyzed according to disease (HUS group or other etiologies) and the type of anticoagulation used.
Results:
The median lifespan of the filters in the HUS group was shorter than that in the other etiologies group (13.3 hours vs. 17.6 hours, P=0.05). This study revealed no significant difference in filter lifespan between regional citrate anticoagulation (RCA) and systemic unfractionated heparin (UFH) in pediatric patients with typical HUS (P=1.00).
Discussion:
The prothrombotic nature of HUS, characterized by platelet activation, may contribute to the observed decrease in lifespan. The mechanism of coagulation activation in HUS and its interaction with hemofiltration, including the effects of platelets and blood product transfusions, remain to be explored.
Conclusion:
The lifespan of the filters is shorter in patients with HUS than in those with other etiologies, regardless of the type of anticoagulation used.