Additional file 4. CSV containing genomes for which compatible arrays were found with following columns: accession number genome, compatible subtypes of array, PAM, category.

Figshare2021-10-01 更新40

Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope [DNA-seq]

碱基编辑器

基因编辑优化

Base editors are RNA-guided deaminases that enable site-specific nucleotide transitions. The targeting scope of these Cas-deaminase fusion proteins critically depends on the availability of a protospa

NIAID Data Ecosystem40

High-throughput profiling of base editor activity. Homo sapiens

基因组编辑

碱基编辑器

Base editors are valuable tools for genome editing, but in-depth characterization of base editors is currently limited by a lack of large-scale gRNA activity datasets. Here, we performed a genome-scal

NIAID Data Ecosystem70

Deep sequencing data for PAM-SCANR tested CRISPR-Cas systems

CRISPR-Cas系统

PAM序列

In this work, we analyzed recognized PAM sequences from four CRISPR-Cas systems: E. coli I-E, B. halodurans I-C, S. thermophilus CR1 II-A, and F. novicida V. Cells containing functional PAMs were sort

NIAID Data Ecosystem40

Engineering of adenine base editor with improved editing activity across NNN PAMs. Homo sapiens

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