Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in complex with a synthetic CSIM tetrapeptide from the C-terminus of prelamin A

Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in complex with a synthetic CSIM tetrapeptide from the C-terminus of prelamin A Descriptor: CAAX PRENYL PROTEASE 1 HOMOLOG, PRELAMIN-A/C, ZINC ION Authors: Pike, A.C.W, Dong, Y.Y, Quigley, A, Dong, L, Savitsky, P, Cooper, C.D.O, Chaikuad, A, Goubin, S, Shrestha, L, Li, Q, Mukhopadhyay, S, Yang, J, Xia, X, Shintre, C.A, Barr, A.J, Berridge, G, Chalk, R, Bray, J.E, von Delft, F, Bullock, A, Bountra, C, Arrowsmith, C.H, Edwards, A, Burgess-Brown, N, Carpenter, E.P. Deposit date: 2012-11-01 Release date: 2012-12-05 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.8 Å) Cite: The Structural Basis of Zmpste24-Dependent Laminopathies. Science, 339, 2013人类核膜锌金属蛋白酶ZMPSTE24突变体（E336A）与来自前核纤层蛋白A（prelamin A）C端的合成CSIM四肽的复合物晶体结构 描述：CAAX异戊烯蛋白酶1同源物、前核纤层蛋白A/C、锌离子 作者：Pike, A.C.W、Dong, Y.Y、Quigley, A、Dong, L、Savitsky, P、Cooper, C.D.O、Chaikuad, A、Goubin, S、Shrestha, L、Li, Q、Mukhopadhyay, S、Yang, J、Xia, X、Shintre, C.A、Barr, A.J、Berridge, G、Chalk, R、Bray, J.E、von Delft, F、Bullock, A、Bountra, C、Arrowsmith, C.H、Edwards, A、Burgess-Brown, N、Carpenter, E.P. 提交日期：2012-11-01 发布日期：2012-12-05 最后修改日期：2024-05-08 实验方法：X射线衍射（3.8 Å） 引用文献：《Zmpste24依赖型核纤层蛋白病的结构基础》，《科学》（Science），第339卷，2013年