Supporting Information S1 - Population-Level Impact of Active Tuberculosis Case Finding in an Asian Megacity

Figure S1: Relationship of Parameters to Transmission Model of TB Epidemic in Karachi. This figure provides a visual perspective on the parameters used in the model and is not designed to be a mathematically complete formulation (as appears in the following sections). Each set of parameters must be multiplied by the size of the preceding box to obtain the corresponding rate of change. Mortality from TB (μsp and μsn) is included in the model but not shown here. Table S1. Model Parameters. Shown are all model parameters used, with corresponding values and references. Figure S2: Distribution of ages (in years) within the TB model. The age distribution was derived through the convolution of all 9 exponentially distributed age classes, the first having a mean of 10 years and the subsequent 8 with a mean of 5 years. Table S2: Fit for high and low incidence scenarios, 2008-2011. Shown are the fitted parameter values for high and low incidence scenarios, respectively. Table S3: Duration of active TB (years) in each model year including self-cure and mortality. These data correspond to the prevalence/incidence ratio for each form of active TB, in each year shown. Table S4: Ranges of rate of detection and treatment used in sensitivity analyses.
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