The transcriptional profile of neutrophils in different organs during pancreatic cancer

It was previously demonstrated that myeloid cells assume a distinct transcriptional profile when infiltrating the brain during chronic inflammation. We demonstrated that neutrophils infiltrate the brain during pancreatic cancer. To determine if the transcriptional profile of brain-infiltrating neutrophils is distinct from those infiltrating other organs, we compared the gene signatures of brain-infiltrating neutrophils, circulating neutrophils, liver-infiltrating neutrophils, and tumor-infiltrating neutrophils to that of circulating neutrophils from healthy mice. Brain-infiltrating neutrophils (n=4), Liver-infiltrating neutrophils (n=4), Tumor-infiltrating neutrophils (n=4), Circulating neutrophils (from tumor-bearing mice) (n=4), Circulating neutrophils (from sham mice) (n=4)