The diagnostic performance of the FIB-4 index for detecting significant fibrosis, severe fibrosis and cirrhosis.

ΔThe disease spectrum of some studies [11], [17], [19]–[21], [24], [26]–[28] were not in good accordance with our study, thus they were excluded for sensitivity analysis.
*The studies in which the reference standard results were interpreted without knowledge of the results of the index tests, were grouped into “Blindness”.
The “proper interval” was defined as the time interval between the determination of the FIB-4 index and liver biopsy was no longer than 7 days.
#As two studies [22], [32] were written by the same author, the study [32] with the smaller sample size was excluded for sensitivity analysis. 95% CI: 95% confidence interval. DOR: diagnostic odds ratio. PLR: positive likelihood ratio; NLR: negative likelihood ratio. AUHSROC: area under the hierarchical summary receiver operating characteristic curve.
The diagnostic performance of the FIB-4 index for detecting significant fibrosis, severe fibrosis and cirrhosis.