Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor

Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor Descriptor: (2~{S})-2-(2-fluorophenyl)-2-[4-(2-methylpyrimidin-5-yl)phenyl]-~{N}-oxidanyl-ethanamide, Histone deacetylase 4, SODIUM ION, ... Authors: Luckhurst, C.A, Maillard, M.C, Dominguez, C. Deposit date: 2018-03-13 Release date: 2018-12-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg. Med. Chem. Lett., 29, 2019一种可穿透中枢神经系统（CNS）的二苯甲基羟肟酸类IIa型组蛋白去乙酰化酶（histone deacetylase, HDAC）抑制剂的开发与表征。描述符：(2S)-2-(2-氟苯基)-2-[4-(2-甲基嘧啶-5-基)苯基]-N-羟基乙酰胺、组蛋白去乙酰化酶4（HDAC4）、钠离子……作者：Luckhurst, C.A、Maillard, M.C、Dominguez, C.存档日期：2018-03-13；发布日期：2018-12-05；最后修改日期：2024-01-17。测试方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.15 Å）。引用：《一种可穿透中枢神经系统（CNS）的二苯甲基羟肟酸类IIa型组蛋白去乙酰化酶抑制剂的开发与表征》，《Bioorg. Med. Chem. Lett.》，第29卷，2019年。