Structure of Mycobacterium tuberculosis InhA in complex with pyridomycin-derivative KV29a (compound 5)

Structure of Mycobacterium tuberculosis InhA in complex with pyridomycin-derivative KV29a (compound 5) Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH], ~{N}-[(2~{Z},5~{R},6~{S},9~{S},10~{S},11~{R})-2-butan-2-ylidene-5,11-dimethyl-10-oxidanyl-3,7,12-tris(oxidanylidene)-9-(pyridin-3-ylmethyl)-1,4-dioxa-8-azacyclododec-6-yl]-4-oxidanyl-pyridine-3-carboxamide Authors: Publicola, G, Mourey, L, Valderrama, K, Hartkoorn, R, Maveyraud, L. Deposit date: 2025-06-12 Release date: 2026-02-11 Last modified: 2026-02-25 Method: X-RAY DIFFRACTION (1.766 Å) Cite: Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach. J.Med.Chem., 69, 2026结核分枝杆菌（Mycobacterium tuberculosis）InhA与吡里霉素衍生物KV29a（化合物5）的复合物晶体结构 描述符：烯酰-[酰基载体蛋白]还原酶[NADH]，N-[(2Z,5R,6S,9S,10S,11R)-2-丁-2-亚基-5,11-二甲基-10-羟基-3,7,12-三氧代-9-(吡啶-3-基甲基)-1,4-二氧杂-8-氮杂环十二烷-6-基]-4-羟基吡啶-3-甲酰胺 作者：Publicola G、Mourey L、Valderrama K、Hartkoorn R、Maveyraud L 沉积日期：2025-06-12 发布日期：2026-02-11 最后修改日期：2026-02-25 测试方法：X射线衍射（分辨率1.766埃） 引用文献：《通过半合成策略优化吡里霉素的抗菌活性与代谢稳定性》，《药物化学杂志》（J.Med.Chem.），第69卷，2026年