Data From QIN GBM Treatment Response

This collection contains “double baseline” multi-parametric MRI images collected on patients with newly diagnosed glioblastoma. The patients were scanned after surgery but prior to the start of therapy, typically 2-5 days apart. The structural images included T1-weighted pre- and post-contrast images, T2-weighted images, FLAIR and MEMPRAGE images. Advanced MRI sequences included Diffusion Weighted (DW) Imaging, Dynamic Contrast-Enhanced MRI (DCE-MRI), and Dynamic Susceptibility Contrast MRI (DSC-MRI). The value of this collection is to provide clinical image data to establish the test-retest characteristics of parameters calculated from DW-MRI, DCE-MRI, and DSC-MRI such as ADC, Ktrans and rCBV. Data were provided by Dr. Elizabeth Gerstner and Dr. Kalpathy-Cramer (MGH) as part of their participation in the Quantitative Imaging Network. The images were obtained on 32-channel Siemens Trio 3T scanners using Siemens 32-channel head coils. T1-weighted imaging was performed using a 2D FLASH sequence with TR/TE/α = 600 ms/12 ms/90°, matrix size 256 × 216, field of view (FOV ) 185mm × 220mm, 23 slices and 5mm slice thickness. T2-weighted imaging was performed using a 3D SPACE spin-echo sequence with TR/TE = 3200 ms/428 ms, matrix size 256 × 258, FOV 256mm × 256mm, 176 slices and 1mm slice thickness. FLAIR was performed using a 2D spin-echo inversion-recovery sequence with TR/TI/TE = 10000 ms/2500 ms/70 ms, matrix size 256 × 162, FOV 185mm × 220mm, 23 slices and 5mm slice thickness. MEMPRAGE was performed using a 3D multi-echo Magnetization Prepared Rapid Gradient Echo sequence with TR/TI/TE1/TE2/TE3/TE4/α =2530 ms/1200 ms/1.64 ms/3.5 ms/5.36 ms/7.22 ms/7°, matrix size 256 × 256, FOV 256mm × 256mm, 176 slices and 1mm slice thickness. A DW echo planar imaging sequence with trace diffusion sensitization and b-values of 0 and 700 s/mm2, TR/TE = 7980 ms/84 ms, matrix size 128 × 128, FOV 237mm × 237mm, 64 slices and 1.86mm slice thickness, provided data for Apparent Diffusion Coefficient (ADC) maps. To estimate pre-contrast T1 relaxation time for DCE quantitation purposes, T1 mapping was performed by using a 3D FLASH sequence before the injection of contrast agent with TR/TE = 7.3 ms/4.41 ms, matrix size 128 × 128, FOV 230mm × 230mm, 20 slices, and 2.1mm slice thickness. This sequence was repeated five times at five different flip-angles of 2°, 5°,10°,15°, and 30°. DCE MRI utilized a 3D FLASH dual gradient-echo sequence with with TR/TE1/TE2/α = 6.8 ms/2.61 ms/3.89 ms/10°, matrix size 128 × 128, FOV 230mm × 230mm, 20 slices and 2.1mm slice thickness. The acquisition was repeated for 60 times (frames) for a total scan time of 6 min, corresponding to a temporal resolution of 6 s. A bolus of 0.1 mmol/kg of Gd-DTPA (gadopentetic acid) was injected 52 s after the scan started. Finally, a combined gradient-echo (ge) and spin-echo (se) 2D EPI sequence was performed to acquire DSC-MRI data with TR/TE(ge)/TE(se)/α = 1500 ms/31 ms/95 ms/80°, matrix size 160 × 160, FOV 192mm × 192mm, 12 slices and 5mm slice thickness. The acquisition was repeated 100 times for a total scan time of 2 min and 41 sec, corresponding to a temporal resolution of 1.61 s. A bolus of 0.1 mmol/kg of GD-DTPA was injected 80 s after the scan started.

本数据集收录了针对初诊胶质母细胞瘤患者采集的"双基线"多参数磁共振成像（MRI）图像。所有患者均在术后、治疗开始前完成两次扫描，两次扫描间隔通常为2至5天。该数据集包含的结构成像包括T1加权对比前、对比后图像、T2加权图像、液体衰减反转恢复（FLAIR）序列以及磁化准备快速梯度回波（MEMPRAGE）序列；高级MRI序列则涵盖弥散加权成像（DW Imaging）、动态对比增强磁共振成像（DCE-MRI）与动态磁敏感对比磁共振成像（DSC-MRI）。本数据集的核心价值在于提供临床影像数据，用于确立由DW-MRI、DCE-MRI与DSC-MRI计算得到的参数（如表观扩散系数（ADC）、转运常数Ktrans以及相对脑血容量rCBV）的重测特性。本数据集由伊丽莎白·格斯特纳博士与卡尔帕蒂-克拉默博士（麻省总医院MGH）提供，作为其参与定量成像网络（Quantitative Imaging Network）的研究成果之一。所有图像均采用西门子32通道头部线圈，在32通道西门子Trio 3T磁共振扫描仪上采集。T1加权成像采用2D快速小角度激发（FLASH）序列，重复时间（TR）/回波时间（TE）/翻转角（α）=600ms/12ms/90°，矩阵尺寸256×216，视野（FOV）185mm×220mm，共23层，层厚5mm。T2加权成像采用3D采样完美稳态序列（SPACE）自旋回波序列，TR/TE=3200ms/428ms，矩阵尺寸256×258，FOV 256mm×256mm，共176层，层厚1mm。FLAIR序列采用2D自旋回波反转恢复序列，TR/反转时间（TI）/TE=10000ms/2500ms/70ms，矩阵尺寸256×162，FOV 185mm×220mm，共23层，层厚5mm。MEMPRAGE序列采用3D多回波磁化准备快速梯度回波序列，TR/TI/TE1/TE2/TE3/TE4/α=2530ms/1200ms/1.64ms/3.5ms/5.36ms/7.22ms/7°，矩阵尺寸256×256，FOV 256mm×256mm，共176层，层厚1mm。弥散加权回波平面成像（DW-EPI）序列采用追踪扩散敏感方案，b值分别为0和700s/mm²，TR/TE=7980ms/84ms，矩阵尺寸128×128，FOV 237mm×237mm，共64层，层厚1.86mm，用于生成表观扩散系数（ADC）图。为估算DCE-MRI定量分析所需的对比前T1弛豫时间，研究人员在对比剂注射前采用3D FLASH序列完成T1 mapping成像，参数为TR/TE=7.3ms/4.41ms，矩阵尺寸128×128，FOV 230mm×230mm，共20层，层厚2.1mm，该序列分别以2°、5°、10°、15°和30°五种不同翻转角重复采集五次。DCE-MRI采用3D FLASH双梯度回波序列，TR/TE1/TE2/α=6.8ms/2.61ms/3.89ms/10°，矩阵尺寸128×128，FOV 230mm×230mm，共20层，层厚2.1mm。该采集序列重复60次（共60帧），总扫描时长6分钟，时间分辨率为6秒。扫描开始52秒后，以0.1mmol/kg的剂量团注钆喷酸葡胺（Gd-DTPA，gadopentetic acid）。最后，采用梯度回波（GE）与自旋回波（SE）联合的2D回波平面成像（EPI）序列采集DSC-MRI数据，参数为TR/TE(GE)/TE(SE)/α=1500ms/31ms/95ms/80°，矩阵尺寸160×160，FOV 192mm×192mm，共12层，层厚5mm。该采集序列重复100次，总扫描时长2分41秒，时间分辨率为1.61秒。扫描开始80秒后，以0.1mmol/kg的剂量团注钆喷酸葡胺（GD-DTPA）。