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One-Step Synthesis of Saturated Spirocyclic N‑Heterocycles with Stannyl Amine Protocol (SnAP) Reagents and Ketones

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NIAID Data Ecosystem2026-03-09 收录
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https://figshare.com/articles/dataset/One_Step_Synthesis_of_Saturated_Spirocyclic_N_Heterocycles_with_Stannyl_Amine_Protocol_SnAP_Reagents_and_Ketones/2222599
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资源简介:
The combination of cyclic ketones and stannyl amine protocol (SnAP) reagents affords saturated, spirocyclic N-heterocycles under operationally simple reaction conditions. The resulting, N-unprotected spirocyclic amines are in great demand as scaffolds for drug discovery and development. The union of SnAP reagents and acyclic trifluoro­methyl­ketones yields α-CF3 morpholines and piperazines.
创建时间:
2016-02-16
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