Crystal structure of human TRF1 TRFH domain in complex with compound 16

Crystal structure of human TRF1 TRFH domain in complex with compound 16 Descriptor: 5-cyclobutyl-3-pyridin-2-yl-1,2,4-oxadiazole, DIMETHYL SULFOXIDE, Telomeric repeat-binding factor 1 Authors: Casale, G, Le Bihan, Y.-V, van Montfort, R.L.M, Guettler, S. Deposit date: 2024-11-15 Release date: 2025-11-26 Last modified: 2025-12-03 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Discovery of first-in-class inhibitors of the TRF1:TIN2 protein:protein interaction by fragment screening. Sci Rep, 15, 2025