Adverse events reported in the studies in healthy volunteers.

Treat = treatment; NR = not reported; RR = relative risk; CI = confidence interval; IV = intravenous; AE = adverse effects.aas reported by authors.breason dropout not reported.cvery limited reporting adverse events.dbackache.edizziness; lightheadedness.foverall percentage (all groups).grash; dizziness and tachycardia.hmoderate headache with increasing intensity; repeated vomiting.imoderate rash (n = 3); mild nausea.jliver function and hematologic abnormalities.