Supporting data for "Molecular and Functional Characterization of Peroxisomal MAVS in innate immunity"

This research projects aims to characterise the molecular function of MAVS from peroxisomes. MAVS is an essential adaptor molecule in type I IFN signalling, which takes place in mitochondria. Currently, MAVS has been found to reside in peroxisomes, which emerges to be another anti-viral platform. MAVS has known to form functional aggregates to transmit signals for inducing type I IFN. Considering the small size of peroxisomes, we doubt whether peroxisomal MAVS also forms aggregates. Also, whether MAVS induces type I IFN from peroxisome remains unclear. We have determined that peroxisomal MAVS induce type I IFN expression.