HDAC1 regulates effector CD8+ T cell differentiation during chronic viral infection
收藏NIAID Data Ecosystem2026-05-02 收录
下载链接：
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE271531
下载链接
链接失效反馈官方服务：
资源简介：
Hdac1 is a known epigenetic regulator of gene expression. The aim of this study is to investigate whether Hdac1 influences CD8+ T cell fate during chronic infection. We demonstrate that the genetic ablation of Hdac1 reduces the generation of Tex-Int cells Gzmb-Cre; Rosa26-lsl-GFP; Hdac1 wild-type or floxed mice were directly infected with LCMV Clone 13. On day 8 post-infection, Gp33 tetramer-positive cells were sorted into three populations based on surface markers Cx3cr1 and Slamf6 for ATAC-seq analysis.
创建时间：
2025-07-23
