Expression and Possible Mechanism of circular RNA rno_CIRCpedia_1953 in Deep Venous Thrombosis (RNA)

Conclusions: Animal model of DVT in rats was successfully established by stenosis method. High-throughput sequencing analysis of circRNAs showed that circRNAs participated in the evolution of DVT. According to STEM functional analysis of mRNA sequencing, a target circRNA rno_CIRCpedia _1953 was screened, verified and identified. rno_CIRCpedia_1953 may participate in the development of DVT by acting as miRNA molecular sponge.研究结论：采用狭窄造模法成功构建了大鼠深静脉血栓（Deep Vein Thrombosis, DVT）动物模型。通过环状RNA（circular RNA, circRNA）高通量测序分析，证实circRNA参与了深静脉血栓的病程演进。基于mRNA测序的短时程表达谱聚类（STEM）功能分析，筛选、验证并鉴定出一条目标环状RNA rno_CIRCpedia_1953。rno_CIRCpedia_1953或可通过充当微小RNA（microRNA, miRNA）分子海绵参与深静脉血栓的发生发展。