Erythroderma combined with deeper dermal dermatophytosis due to Trichophyton rubrum in a patient with myasthenia gravis: first case report and literature review

The dataset includes the following content:Patient's skin lesion photos, pathological tissue examination photos, and strain morphology photos. Figure 1 shows the clinical presentation of the patient. a-h Erythema accompanied by scales covered the patient’s body, and multiple disseminated, firm and dusky red to purple nodules and plaques were distributed over his trunk (a, b), arms (c, d , g) and lower extremities (e, f), presenting with crusts and erosions. (h) All toenails were thickened, dystrophic and showed yellowish discoloration. Figure 2 provides histological descriptions of the erythema and nodules.Histological description of the erythema and nodules. a, b Histological examination of the erythema revealed epidermal hyperplasia and hypertrophy, infectious granuloma in the dermis, and dense inflammatory infiltrate consisting of epithelioid cells, lymphocytes, plasma cells, neutrophils, and scattered multinucleated giant cells. Hematoxylin and eosin (HE) ×100 (a), HE ×200 (b). c, d Histopathology of the nodules revealed pseudoepitheliomatous epidermal hyperplasia, inflammatory granulomatous infiltration, and dense inflammatory infiltration in the dermis, with infiltrating cells identical to those of the erythema. HE, ×20 (c), HE, ×100 (d). e-g Hyphae (white arrow) and conidia (red arrow) in the corneum (e) and dermis (f, g). Periodic acid-Schiff stain, ×200.Scale bar, 20 µm. Figure 3 presents the fungal examination results.a KOH wet mount and direct microscopic examination of the scrapings from the patient’s trunk showing abundant septate hyphae. ×200. b Small white fluffy and creamy yellow colonies were observed on potato dextrose agar plate after 1 week of culturing at 28°C. c Macroconidia (black arrow) and microconidia (red arrow) were observed under lactate phenol medan staining with an optical microscope. Scale bar, 20 µm. Figure 4 depicts the clinical presentation of the patient after treatment. a–c After receiving antifungal treatment for 14 days, the patient's erythema and scales partially subsided. ITS sequences of the clinical strain.Table 1 summarizes a published paper titled "Characterization of patients with dermatophyte-related erythroderma" Abbreviations: M: male; F: female; DM: diabetes mellitus; ITR: itraconazole; KCZ: ketoconazole; GSF: griseofulvin; AMB: amphotericin B; IV: intravenous injection; m: mounth; CR: complete response.ND: not described; Table 2 summarizes a published paper titled "Characterization of patients with deeper dermal dermatophytosis caused by T. rubrum" Abbreviations: M: male; F: female; ND: not described; y: year; d: day; tx: transplantation; DM: diabetes mellitus; Y: yes; N: no; ITR: itraconazole; POS: posaconazole; VOR: voriconazole TER: terbinafine; KCZ: ketoconazole; GSF: griseofulvin; EX: excisional surgery; AMB: amphotericin B; IV: intravenous injection; m: mounth; w: week; CR: complete response; UK: unknow