Enzyme-treated Polygonatum odoratum alleviates cyclophosphamide-induced immune injury by modulating the liver-gut axis and the JAK/STAT3 signaling pathway

ETP treatment significantly alleviated CTX-induced dysbiosis of the gut microbiota and improved its diversity. Furthermore, it effectively suppressed the activation of the JAK-STAT3 signaling pathway. These superior effects, compared to the conventional extract, are linked to ETP's unique chemical profile, which is characterized by a higher abundance of bioactive terpenoids and flavonoids.