Cyclic Alkenenitriles: Copper-Catalyzed Deconjugative α‑Alkylation
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https://figshare.com/articles/dataset/Cyclic_Alkenenitriles_Copper_Catalyzed_Deconjugative_Alkylation/3371101
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资源简介：
An
amido cuprate formed from CuCN and LDA allows a general deconjugative
α-alkylation of cyclic alkenenitriles. Deprotonating cyclic
alkenenitriles with LDA-CuCN avoids polymerization that otherwise
plagues these alkylations and generates a reactive metalated nitrile
for alkylations with a range of carbon and heteroatom electrophiles.
The strategy provides an effective synthesis of quaternary 5-, 6-,
and 7-membered cycloalk-1-enecarbonitriles substituted on the nitrile-bearing
carbon.
创建时间：
2016-05-16
