Gene expression profiles of wild-type and PERK-deficient cells during activation of OXPHOS

Intracellular ATP is mainly produced by the glycolysis pathway in culture cells incubated with high-glucose medium, whereas ATP production is switched to the OXPHOS pathway by culturing with the no-glucose medium. To elucidate the potential function of PERK during activation of OXPHOS pathway, we perfomed RNA-sequencing analayais using wild-type and PERK-deficient HEK293 cells. Examination of gene expression in wild-type and PERK-deficient HEK293 cells during activation of OXPHOS.