Plasma cytokine concentrations 2 days post initiation of treatment.

All data are presented as median (IQR) values.*Fever day (median (IQR) refers to the day of sampling relative to the day of defervescence, defined as fever day 0.**Trend test using multivariable linear regression of log transformed values adjusted for pre-treatment value and day of illness at enrolment. The effect corresponds to the estimated multiplicative difference between low-dose vs. placebo or high-dose vs. low-dose, respectively, which were assumed to be identical as a linear dose-response effect was estimated.