Supplementary Material for: Cervical Lymphadenopathy in Concomitant CML and Tuberculosis: A Case Report

Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder characterized by the uncontrolled proliferation of mature and maturing granulocytes in the bone marrow, along with the presence of the Philadelphia chromosome. Lymphadenopathy is an uncommon initial manifestation of CML and is often attributed to the disease itself. However, with the use of tyrosine kinase inhibitors (TKIs), which can affect T-cell mediated immunity, new or persistent lymphadenopathy in CML patients should prompt investigation to rule out opportunistic infections, including tuberculosis (TB), and CML blast phase. We present the case of a 35-year-old male with chronic-phase CML who initially presented with cervical lymphadenopathy, which was initially attributed to CML. However, further evaluation through lymph node biopsy revealed concurrent TB. After initiating appropriate treatment, the lymphadenopathy resolved. This case emphasizes the importance of considering opportunistic infections, such as TB, in CML patients, particularly those on TKI therapy, when lymphadenopathy is present.