Crystal structure of CHK1-10pt-mutant complex with compound 32
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Crystal structure of CHK1-10pt-mutant complex with compound 32 Descriptor: 4-amino-2-[(1,3-dimethyl-1H-pyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, CHLORIDE ION, Serine/threonine-protein kinase Chk1 Authors: Dokurno, P, Surgenor, A.E, Williamson, D.S. Deposit date: 2021-01-15 Release date: 2021-07-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate. J.Med.Chem., 64, 2021
CHK1-10pt突变体与化合物32复合物的晶体结构 描述符：4-氨基-2-[(1,3-二甲基-1H-吡唑-4-基)氨基]-7-甲基-6-[(2R)-2-甲基吡咯烷-1-基]-7H-吡咯并[2,3-d]嘧啶-5-甲腈、氯离子、丝氨酸/苏氨酸蛋白激酶CHK1 作者：Dokurno, P、Surgenor, A.E、Williamson, D.S. 存放日期：2021-01-15 发布日期：2021-07-07 最后修改日期：2024-01-31 测试方法：X射线衍射（2 Å） 引用文献：《利用检查点激酶1（Checkpoint Kinase 1, CHK1）晶体替代物设计并合成吡咯并[2,3-d]嘧啶类富亮氨酸重复激酶2（Leucine-Rich Repeat Kinase 2, LRRK2）抑制剂》，《药物化学杂志（J.Med.Chem.）》，2021年，第64卷
