Structure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs

Structure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs Descriptor: 2-(5-chlorothiophen-2-yl)-N-[(3S)-1-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-2-oxopyrrolidin-3-yl]ethanesulfonamide, ACTIVATED FACTOR XA HEAVY CHAIN, ACTIVATED FACTOR XA LIGHT CHAIN, ... Authors: Young, R.J, Borthwick, A.D, Brown, D, Burns-Kurtis, C.L, Campbell, M, Chan, C, Charbaut, M, Convery, M.A, Diallo, H, Hortense, E, Irving, W.R, Kelly, H.A, King, N.P, Kleanthous, S, Mason, A.M, Pateman, A.J, Patikis, A, Pinto, I.L, Pollard, D.R, Senger, S, Shah, G.P, Toomey, J.R, Watson, N.S, Weston, H.E, Zhou, P. Deposit date: 2007-11-16 Release date: 2008-11-25 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs. Bioorg. Med. Chem. Lett., 18, 2008基于结构与性质的因子Xa（Factor Xa）抑制剂设计：引入碱性杂环基元的联芳基吡咯烷-2-酮类化合物 描述符：2-(5-氯噻吩-2-基)-N-[(3S)-1-(4-{2-[(二甲氨基)甲基]-1H-咪唑-1-基}-2-氟苯基)-2-氧代吡咯烷-3-基]乙磺酰胺、活化因子Xa重链（Activated Factor Xa Heavy Chain）、活化因子Xa轻链（Activated Factor Xa Light Chain）等 作者：Young, R.J、Borthwick, A.D、Brown, D、Burns-Kurtis, C.L、Campbell, M、Chan, C、Charbaut, M、Convery, M.A、Diallo, H、Hortense, E、Irving, W.R、Kelly, H.A、King, N.P、Kleanthous, S、Mason, A.M、Pateman, A.J、Patikis, A、Pinto, I.L、Pollard, D.R、Senger, S、Shah, G.P、Toomey, J.R、Watson, N.S、Weston, H.E、Zhou, P 提交日期：2007-11-16 发布日期：2008-11-25 最后修改日期：2024-11-06 测试方法：X射线衍射（X-RAY DIFFRACTION，1.7 Å） 引用文献：基于结构与性质的因子Xa抑制剂设计：引入碱性杂环基元的联芳基吡咯烷-2-酮类化合物. 《生物有机与药物化学快报》（Bioorg. Med. Chem. Lett.），18卷，2008年