Left ventricular work.

Left ventricular work was estimated as the product of heart rate (HR) and systolic arterial pressure (bp sys). Relative cardiac output was estimated as the product of heart rate and relative stroke volume (integral of the arterial curve). dP/dt max of the arterial pressure curve did not show a NS1619-dependent variation. Data obtained after inhalation were subtracted from individual basis values and individual value differences (Δ) were calculated for each animal and time point. (Solvent: n = 10; 12 µM: n = 7, 100 µM: n = 7; ∑NS1619: n = 14;*: p<0.05).