Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Ortho-chlro-sulfonyl-piperazine Inhibitor

Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Ortho-chlro-sulfonyl-piperazine Inhibitor Descriptor: 3-chloro-4-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)benzamide, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Bard, J, Svenson, K. Deposit date: 2009-04-23 Release date: 2009-12-01 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.187 Å) Cite: Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model. J.Med.Chem., 52, 2009人类11β-羟类固醇脱氢酶（human 11-beta-hydroxysteroid-dehydrogenase）与邻氯磺酰基哌嗪类抑制剂结合的晶体结构 配体描述：3-氯-4-({(2R)-4-[4-氟-2-(三氟甲基)苯基]-2-甲基哌嗪-1-基}磺酰基)苯甲酰胺 靶标：类固醇11β-脱氢酶同工酶1（Corticosteroid 11-beta-dehydrogenase isozyme 1）、烟酰胺腺嘌呤二核苷酸磷酸（nicotinamide-adenine-dinucleotide phosphate, NADP） 作者：Bard J、Svenson K 沉积日期：2009-04-23 发布日期：2009-12-01 最后修改日期：2024-02-21 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.187埃（Å） 引用文献：饮食诱导肥胖小鼠模型中的强效11β-羟类固醇脱氢酶1型抑制剂，J.Med.Chem., 52, 2009